Compare Sudafed vs. Afrin Head-to-head comparisons of medication uses, side effects, ratings, and more. Oxymetazoline is a topical decongestant, used in the form of oxymetazoline hydrochloride.It was developed from xylometazoline at E. Merck Darmstadt by Fruhstorfer in 1961. Nasal sprays became over-the-counter drugs in 1975 after initial success as prescription medications. Find out more about the different types of … Afrin (oxymetazoline) clears stuffy noses, but can worsen your congestion if it is … BackgroundOxymetazoline and xylometazoline are locally effective and direct acting drugs that relieve nasal congestion. Often times there are good for patients who have epistaxis. Oxymetazoline belongs to a class of drugs called Imidazolines and has a longer duration of action than phenylephrine. Nasal sprays can relieve a congested nose or throat, but people can develop a dependence with some types. The aim of this study was to objectively determine and compare the decongestive effects of oxymetazoline and xylometazoline in healthy subjects.MethodsThe study population comprised thirty healthy adults. For those people who have used decongestant nasal sprays with oxymetazoline (Afrin) or xylometazoline (Otrivine), what's the difference in duration of effect and also, which one gives the most rebound swelling when using for multiple days? Afrin (oxymetazoline) clears stuffy noses, but can worsen your congestion if it is used more frequently than 3 days in a row. Uses Oxymetazoline works by constricting … There are two strengths of xylometazoline nose drops. We conclude that long-term use of xylometazoline nasal spray shortens the decongestive response in healthy volunteers. The active ingredients in these products – ephedrine, epinephrine, naphazoline, oxymetazoline, phenylephrine, pseudoephedrine, tetrahydrozoline, and xylometazoline – are low risk, with one caveat: I would avoid using pseudoephedrine in the first trimester … Phenylephrine does not get into the brain very easily, but if it did it probably would stimulate the brain. The sprays are good to keep the nose moist, but they are unlikely to help with nasal congestion. These sprays contain saline. There is an adult strength of 0.1%, and a child strength of 0.05% which is suitable for children aged 6 years or over. The more often a person uses chemicals such as phenylephrine, xylometazoline and oxymetazoline, the worse their chronic symptoms become over time. A nasal spray is available for adults and for children over 12 years of age. Astepro (azelastine) is an antihistamine nasal spray that can help with allergy or nasal symptoms. Menu. Thanks. Brand- Afrin, Sinex, Dristan, Zicam . Don't forget your photo ID or you won't be able to buy it in the drugstore. Problems occur if you are tempted to spray a little more or a little longer, in spite of the instructions, which say ten days max. Classification The active ingredient, Oxymetazoline hydrochloride is classified as a topical decongestant. The active substances xylometazoline and oxymetazoline cause blood vessels in the nasal mucosa to contract, which allows freer breathing. Most nasal sprays contain Oxymetazoline hydrochloride which was developed from xylometazoline at E. Merck Darmastadt by Fruhstorfer in 1961. Skip to: full site navigation. Generic- Oxymetazoline, phenylephrine, xylometazoline, naphazoline, neo-synephrine . Nasal saline spray or gel. I only have used a phenylefrine nasal spray and it only works for like 3 hours. When comparing the results of this trial with the corresponding results of the oxymetazoline study, no further increase in rebound swelling was found. 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