strontium citrate pros and cons

The forms of strontium available over-the-counter in the U.S. or on the Internet are usually strontium citrate or strontium chloride. In nature, it is found in highest amounts in the ocean and consequently in certain bony fish. 1992;71 Spec No:841-845. JAMA 1995;274:420-4. N.Engl.J.Med. Ann Rheum Dis. To measure the effectiveness of it, researchers measured bone mineral density in the neck, spine and hip as well as some biochemical bone markers. Sr should be used with caution for those with kidney disease and if you have advanced kidney disease, then strontium ranelate is not recommended at all. A special form of strontium called strontium ranelate can increase bone formation and prevent bone loss when used in postmenopausal women with osteoporosis. Oral Dis. View abstract. If you want to take a strontium supplement, it is recommended to ask your doctor first. Please note the date of the last review on all articles. Liu, J. M., Wai-Chee, Kung A., Pheng, C. S., Zhu, H. M., Zhang, Z. L., Wu, Y. Y., Xu, L., Meng, X. W., Huang, M. L., Chung, L. P., Hussain, N. H., Sufian, S. S., and Chen, J. L. Efficacy and safety of 2 g/day of strontium ranelate in Asian women with postmenopausal osteoporosis. Natural strontium has a silvery white metallic color with a tint of yellow. Bone 2009;45(2):200-206. View abstract. A., Johansson, H., Oden, A., and McCloskey, E. V. A meta-analysis of the effect of strontium ranelate on the risk of vertebral and non-vertebral fracture in postmenopausal osteoporosis and the interaction with FRAX((R)). So what is stable strontium exactly? The most common form of strontium in nutritional supplements is strontium citrate. It's derived from rock calcium bound with citric acid (think citrus juices, especially lime and lemon). View abstract. 1978;57(9-10):903. Please note the date of the last review on all articles. View abstract. Drug Ther Bull. 2006;54(10):3205-3211. Mayo docs say it will stay in my system for up to three years. Eur.J.Endocrinol. Is Lamb Healthy? O'Donnell S, Cranney A, Wells GA, et al. Roux, C., Reginster, J. Y., Fechtenbaum, J., Kolta, S., Sawicki, A., Tulassay, Z., Luisetto, G., Padrino, J. M., Doyle, D., Prince, R., Fardellone, P., Sorensen, O. H., and Meunier, P. J. Vertebral fracture risk reduction with strontium ranelate in women with postmenopausal osteoporosis is independent of baseline risk factors. Bellamy, N., Campbell, J., Robinson, V., Gee, T., Bourne, R., and Wells, G. Viscosupplementation for the treatment of osteoarthritis of the knee. Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial. A prospective, multicenter, three-month, randomized, double-blind, placebo-controlled trial. It's not known if strontium. View abstract. View abstract. View abstract. Review of clinical studies. Its been compared to calcium in its bone-boosting abilities. View abstract. It may even cause constipation or digestive discomfort. Contact Dermatitis 2000;42(2):98-100. Estrogens might decrease how fast the body gets rid of strontium. Strontium as a marker for intestinal calcium absorption: the stimulatory effect of calcitriol. Meunier PJ, Roux C, Seeman E, et al. Ananthraman, J. and Shahani, S. N. Clinical management of dentin hypersensitivity using cathode and anode iontophoresis. View abstract. @faith123, recently posted about having a second reclast infusion recently here, https://connect.mayoclinic.org/discussion/reclast-infusion/. 2010;6(12):4513-4521. The following doses have been studied in scientific research: Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, Getting Help for a Loved One With Psychosis: It's Complicated, Health News and Information, Delivered to Your Inbox. (3). Because strontium ranelate is a weak anti-resorptive agent and there are more effective osteoporosis agents in the United States and most countries, we do not use strontium ranelate in postmenopausal women with osteoporosis. Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system. In your diet, you get it mainly from seafood, but you can also get small amounts of it in whole milk, wheat bran, meat, poultry, and root vegetables. Arthritis Rheum. Generic drug List. View abstract. Hello @bonelady welcome to Connect. IT was a 9 year nightmare until I started the strontium citrate. J.Periodontol. 1 Taking magnesium oxide with food can reduce stomach troubles. Membership to ConsumerLab.com is available online and provides immediate access to reviews of more than 1,000 products from over 400 brands. 2005;54(9):758-767. 11-30-1995;333(22):1437-1443. Its not an idea that is super-new either. Effect of risedronate on the risk of hip fracture in elderly women. Dermatol.Surg. 2010;21(2):42-48. View abstract. View abstract. Salmon, pink, canned, solids with bone, 3 ounces 181 mg per serving. I did find some information on the Mayo Clinic website on osteoporosis. View abstract. If youre suffering from bone or prostate cancer, radioactive strontium therapyshould only be given by or under the direct supervision of a doctor with specialized training in nuclear medicine or radiation oncology. It is also among the forms of Strontium supplements backed by studies regarding safety and efficiency. You are lucky to still be able to get some control over this. All rights reserved. 7-27-1965;162(989):458-472. 1990;12(4):28-33. Dijkgraaf-Ten Bolscher M, Netelenbos JC, Barto R, van der Vijgh WJ. Strontium ranelate acts through dual mechanisms of inhibiting resorption by osteoclasts and maintaining or stimulating bone formation by osteoblasts. 99% of the strontium found in the human body is in the bone. Today we will talk to our Cleveland Clinic experts regarding steps you can take to prevent this disease and treatments that may be needed. Liberman, U. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Gillam, D. G., Newman, H. N., and Bulman, J. S. The effect of strontium chloride hexahydrate dentifrices on plaque accumulation and gingival inflammation. Osteoporos Int. Strontium can attach to some antibiotics called quinolones in the stomach. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group. You also do not know whether they can seriously harm you. Arch Intern Med 2003;163:1514-22. (21). One study indicated that taking at least three milligrams per day of boron may have anti-inflammatory effects, which can help with osteoarthritis. J.Dent.Res. 12-15-2007;57(8):1410-1418. JAMA 2000;283:1469-75. 2006;3:CD005326. Unfortunately, a lot of toothpastes that contain Sr may contain a lot of other questionable ingredients, so I recommend sticking with a natural toothpaste or making your own at home such as myHomemade Probiotic Toothpaste. Supplements are increasingly available over the counter and through the Internet. Medina, J. M., Thomas, A., and Denegar, C. R. Knee osteoarthritis: should your patient opt for hyaluronic acid injection? They can decrease strontium absorption. (. Available at: https://www.guildlink.com.au/gc/ws/servier/pi.cfm?product=sepproto. Arch.Intern.Med. Most people who take strontium citrate report their fractures STOP. Doctors arent sure exactly how it works, but it seems to help the body make more bone and keep the bone you have from breaking down. Barenholdt, O., Kolthoff, N., and Nielsen, S. P. Effect of long-term treatment with strontium ranelate on bone strontium content. ", UC Davis School of Medicine: "Strontium Citrate for Osteoporosis Prevention Evaluation (SCOPE). 2000;11(1):83-91. J Am Diet Assoc 1987;87:1644-50. Minkoff S, Axelrod S. Efficacy of strontium chloride in dental hypersensitivity. Complete your request online or contact us by phone. 2006;21(7):1113-1120. 1992;23(10):705-711. J.Bone Miner.Res. It was recommended to my sister by her doctor. I have had reclast infusions for six years for osteoporosis. Medical studies done on the ingredients have shown conclusively that this product is effective. 2006;55(8):669-675. Rheumatology (Oxford). Eur.J.Nucl.Med. EPI-GETBP Study Group. Have you ever heard of strontium? Osteoporos.Int. Thromb.Haemost. Boron seems to affect the way the . Effects of long-term strontium ranelate treatment on vertebral fracture risk in postmenopausal women with osteoporosis. View abstract. To avoid this interaction, take antacids at least two hours after taking strontium products. J.Periodontol. I feel that I need something that is shown to rebuild bone (15 lumbar and thoracic vertebral compression fractures). Strontium 89 in the treatment of pain due to diffuse osseous metastases: a university hospital experience. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. Pearce, N. X., Addy, M., and Newcombe, R. G. Dentine hypersensitivity: a clinical trial to compare 2 strontium densensitizing toothpastes with a conventional fluoride toothpaste. View abstract. View abstract. Scientific studies have shown that Sr may have positive effects on bone diseases like osteoporosis, bone cancer, prostate cancer, tooth sensitivity and tooth decay. Arthritis Rheum. View abstract. (Accessed 13 March 2004). Spets-Happonen, S., Seppa, L., Korhonen, A., and Alakuijala, P. Accumulation of strontium and fluoride in approximal dental plaque and changes in plaque microflora after rinsing with chlorhexidine-fluoride-strontium solution. Reginster, J. Y., Deroisy, R., Dougados, M., Jupsin, I., Colette, J., and Roux, C. Prevention of early postmenopausal bone loss by strontium ranelate: the randomized, two-year, double-masked, dose-ranging, placebo-controlled PREVOS trial. McAlindon TE, LaValley MP, Gulin JP, Felson DT. The product can increase bone density, and it can also slow down bone loss. This technology we use to assemble our list depends on a variety of factors, including but not limited to the following: Brand Value: Every brand of strontium citrate . I wont name names, but some of the most well-known toothpastes for sensitive teeth include strontium in their formulas. Reginster, J., Minne, H. W., Sorensen, O. H., Hooper, M., Roux, C., Brandi, M. L., Lund, B., Ethgen, D., Pack, S., Roumagnac, I., and Eastell, R. Randomized trial of the effects of risedronate on vertebral fractures in women with established postmenopausal osteoporosis. Strontium has a chemical similarity to calcium and will replace calcium as the mineral in bone. 2012;23(1):295-303. doi: 10.1007/s00198-011-1547-8. Strontium ranelate may cause unwanted side effects such as stomach pain, diarrhea and headache. . Strontium has a long list of undesirable side-effects, commonly ranging from nausea to skin irritation, and less often (fortunately), blood clots and fainting. Meta-analysis: chondroitin for osteoarthritis of the knee or hip. Delayed strontium absorption in post-menopausal osteoporosis and osteomalacia. Some quinolone antibiotics include ciprofloxacin (Cipro), gemifloxacin (Factive), levofloxacin, moxifloxacin (Avelox), and others. View abstract. Bruyre O, Reginster JY, Bellamy N, et al. It's also known to increase osteoprotegerin that serves as the decoy for the RANKL and slows the rate of bone resorption. Ter.Arkh. View abstract. Pelletier JP, Roubille C, Raynauld JP, et al. Brand: Algaecal. Protelos European Summary of Product Characteristics. View abstract. View abstract. (16), Strontiums name comes from Strontian, a village in Scotland. These side effects may be mild or severe. Strontium ranelate is a form that is sold as a prescription medication for osteoporosis and bone fractures in Europe and Australia. Dose-dependent effects of strontium on osteoblast function and mineralization. View abstract. Les Laboratoires Servier ceased the distribution of Protelos/Osseor in August 2017. Lancet 12-7-1996;348(9041):1535-1541. 1999;25(9):689-694. 2002;13(12):925-931. View abstract. It is an alkaline earth metalmost similar to barium and calcium. View abstract. A., Hoiseth, A., Felsenberg, D., Huss, H., Gilbride, J., Schimmer, R. C., and Delmas, P. D. Effects of oral ibandronate administered daily or intermittently on fracture risk in postmenopausal osteoporosis. Therapeutic Research Faculty 2020. N.Engl.J.Med. This is not the same as making new bone. View abstract. Bingham, C. O., III, Buckland-Wright, J. C., Garnero, P., Cohen, S. B., Dougados, M., Adami, S., Clauw, D. J., Spector, T. D., Pelletier, J. P., Raynauld, J. P., Strand, V., Simon, L. S., Meyer, J. M., Cline, G. A., and Beary, J. F. Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthritis structural arthritis study. Calcif Tissue Int 2001;69:121-9. . Multiple Outcomes of Raloxifene Evaluation (MORE) Investigators. Chesnut III, C. H., Skag, A., Christiansen, C., Recker, R., Stakkestad, J. Strontium ranelate is associated with other harmful effects, including serious skin reactions, disturbances in thinking, seizures, liver inflammation, and reduced numbers of red blood cells. View abstract. Skoryna SC. Selective Estrogen Receptor Modulators (SERMs), Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Smoking Pot Every Day Linked to Heart Risks, Artificial Sweetener Linked to Heart Risks, FDA Authorizes First At-Home Test for COVID and Flu, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Bone Mineral Density Test: What to Expect, Newer Osteoporosis Treatments Build Stronger Bones, Breakfasts for Strong Bones: 12 Foods to Boost Bone Health, Cant move very much, either for a short time, such as after surgery, or for the long term, such as because of a disability. A., Korotkova, T. A., Toroptsova, N. V., Smirnov, A. V., Demin, N. V., Rodionova, S. S., Buklemeshev, IuV, and Shumskii, A. View abstract. View abstract. Rachitogenic activity of dietary strontium. According to Wikipedia, Strontianite(SrCO3) is an important raw material for the extraction ofstrontium. How Well are You Living With Ankylosing Spondylitis? Fidelix, T. S., Soares, B. G., and Trevisani, V. F. Diacerein for osteoarthritis. Bone 2009;45(6):1059-1064. However, there has also been concern over strontium ranelates effects on heart health. A comparative clinical study investigating the efficacy of a dentifrice containing 8% strontium acetate and 1040 ppm fluoride in a silica base and a control dentifrice containing 1450 ppm fluoride in a silica base to provide immediate relief of dentin hypersensitivity. Basically, it is like you are consuming rocks. Eur Urol 2003;44:519-26. I now take 680 mg strontium citrate without side effects and the fractures have stopped. View abstract. Strontium-89 chloride in the treatment of bone metastases from breast cancer. 1978;49(5):269-272. Form: Capsules. (17), In the 19th century, the first large scale use of strontium took place when it was employed to extract the sugar from sugar beets. Spector, T. D., Conaghan, P. G., Buckland-Wright, J. C., Garnero, P., Cline, G. A., Beary, J. F., Valent, D. J., and Meyer, J. M. Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173]. View abstract. (24, 25). If you check your calcium supplement and the supplement facts include calcium carbonate, calcium citrate, or some other name, it is simply ground rocks. https://americanbonehealth.org/bonesense/why-strontium-is-not-good-for-bone-health/ Gillam, D. G., Bulman, J. S., Jackson, R. J., and Newman, H. N. Comparison of 2 desensitizing dentifrices with a commercially available fluoride dentifrice in alleviating cervical dentine sensitivity. Available at: www.servier.com/pro/osteoporose/protelos/protelos_spc.asp. Schrooten I, Elseviers MM, Lamberts LV, et al. JAMA 10-13-1999;282(14):1344-1352. 2007;19(4):330-333. It does not recommend it as a treatment for anyonewho has or has had heart or circulatory problems such as stroke, heart attack, or obstruction of the blood flow in the arteries. View abstract. Its also used to create that alerting red color in emergency flares. Arthritis Rheum 2007;56(7):2267-2277. However, supplementation with strontium has not yet been studied as tooth decay prevention. It is also shown to positively impact the body's usage of testosterone, estrogen, and vitamin D. Cummings, S. R., Black, D. M., Thompson, D. E., Applegate, W. B., Barrett-Connor, E., Musliner, T. A., Palermo, L., Prineas, R., Rubin, S. M., Scott, J. C., Vogt, T., Wallace, R., Yates, A. J., and LaCroix, A. View abstract. OTHER NAME(S): Atomic number 38, Chlorure de Strontium, Chlorure, Strontium is a silvery metal found naturally as a non-radioactive element. Mazor, Z., Brayer, L., Friedman, M., and Steinberg, D. Topical varnish containing strontium in a sustained-release device as treatment for dentin hypersensitivity. A. View abstract. Ann.Rheum.Dis. Good luck to all of you. You can buy different forms of it, such as strontium citrate, in supplements at supermarkets and health food stores. Roux, C., Fechtenbaum, J., Kolta, S., Briot, K., and Girard, M. Mild prevalent and incident vertebral fractures are risk factors for new fractures. 4-12-2005;172(8):1039-1043. Bone 2001;28:446-53. Strontium ranelate is comprised of 27.8% strontium and 72.2% ranelic acid. Protelos European Public Assessment Report, Scientific Discussion. No difference in intestinal strontium absorption after oral or IV calcitriol in children with secondary hyperparathyroidism. Note that the numbers in parentheses (1, 2, etc.) Because strontium and calcium have very similar molecular structures, the body treats them much the same. My Dr wants me to start taking this. Scand J Rheumatol 2001;30(4):242-247. Strontium Boost is supposed to have no side effects at all. Arthritis Res.Ther. A coordinator will follow up to see if Mayo Clinic is right for you. 11 possible benefits. A. Receive updates and information about Bone Health, Our Events, and Specialty Programs each month. 2005 - 2023 WebMD LLC. Faith123 may be able to answer a question or two of yours about the reclast infusion treatment and her experience with it. Marie PJ, Ammann P, Boivin G, Rey C. Mechanisms of action and therapeutic potential of strontium in bone. Accessed May 1, 2018. This decreases the amount of quinolones that can be absorbed. Ann.Rheum.Dis. First, fluoride makes your tooth enamel stronger and less likely to suffer acid damage . This could cause the body to have too much strontium and potentially cause side effects. Methods: Custom-made MDO devices were placed on 20 New Zealand White rabbits. 2014 Apr;61:48-54. doi: 10.1016/j.bone.2014.01.002. View abstract. Pennington JA, Jones JW. Available at: www.emea.eu.int/humandocs/Humans/EPAR/protelos/protelos.htm. Naess, I. Immune function. Osteoporos.Int. Spine (Phila Pa 1976.) Springer, 2019. 2013 Feb;98(2):592-601. doi: 10.1210/jc.2012-3048. Fed.Oper.Dent. View abstract. Pearce, E. I. and Sissons, C. H. The concomitant deposition of strontium and fluoride in dental plaque. 1984;55(12):720-725. Health Phys 2004;86:193-6. Strontium ranelate for preventing and treating postmenopausal osteoporosis. J.Dent. View abstract. It can be found in soil and seawater as well as some foods. Quintessence.Int. 2003;14 Suppl 3:S56-S65. View abstract. Dent.Clin.North Am. It is a member of the aragonite group. (4b) Another mineral containing strontium iscelestite, which is used in strontium metal alloys. Black, D. M., Cummings, S. R., Karpf, D. B., Cauley, J. Here with us today, we have two experts. Do not be misled by marketing materials that compare them to strontium ranelate. View abstract. 2008;67(3):335-339. Some research shows that taking strontium ranelate helps prevent. Ngo, H. C., Mount, G., Mc, Intyre J., Tuisuva, J., and Von Doussa, R. J. N.Engl.J.Med. Peng H, Yao F, Xiong S, Wu Z, Niu G, Lu T. Strontium in public drinking water and associated public health risks in Chinese cities. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. 2010;21(12):1993-2002. Phone & Address: 1-800-820-0184; support@algaecal.com. My fear is the cost. A prescription form of strontiumstrontium ranelate (the ranelate salt), known as Protelos/Osseor was authorized in the European Union to treat severe osteoporosis in women who have been through the menopause and men who are at high risk of broken bones or fracture in the spine and the hip. I was diagnosed with osteopenia", "I have osteoporosis and am afraid of the treatments for it have been trying strontium citrate", "My wife has severe Osteoporosis .It has been improving with Medicines, Yearly injections , Exercise ,". Moise H, Chettle DR, Pejovic-Milic A. 2004;19(8):1241-1249. Hernandez, F., Mohammed, C., Shannon, I., Volpe, A., and King, W. Clinical study evaluating the desensitizing effect and duration of two commercially available dentifrices. Osteoporos.Int. View abstract. 1998;4(2):114-119. Center for drug evaluation and research. 1977;95(5):982-985. View abstract. 2000;57(3):1107-1114. View abstract. April 2004. Bone. No tummy upset this time, have been increasing very slowly as I am very med sensitive, so was on 40mg for 10 days and now 40mg one day and 80 mg every second day for a week, but the tiredness is difficult to put up with. Many formulas for bone health will include a form of Sr. D'Haese, P. C., Schrooten, I., Goodman, W. G., Cabrera, W. E., Lamberts, L. V., Elseviers, M. M., Couttenye, M. M., and De Broe, M. E. Increased bone strontium levels in hemodialysis patients with osteomalacia. Verberckmoes SC, De Broe ME, D'Haese PC. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. Afflitto, J., Schmid, R., Esposito, A., Toddywala, R., and Gaffar, A. Fluoride availability in human saliva after dentifrice use: correlation with anticaries effects in rats. 9-25-2006;166(17):1899-1906. On October 1, 2014 the European Medicines Agencys Pharmacovigilance Risk Assessment Committee (PRAC) recommended that strontium ranelate (Protelos/Osseor, Servier) no longer be used to treat osteoporosis because of data demonstrating serious negative side effects. A consideration of the possible causes of dental hypersensitivity: treatment by a strontium-ion dentifrice. J.Bone Miner.Res. My bone density has shown some improvement and no further decline. Connect with thousands of patients and caregivers for support and answers. Sairanen S, Karkkainen M, Tahtela R, et al. Bianchi ML, Ardissino GL, Schmitt CP, et al. Monitoring bone strontium intake in osteoporotic females self-supplementing with strontium citrate with a novel in-vivo X-ray fluorescence based diagnostic tool. (Strontium may remain in the bones for as long as 710 years after the last dose.) Kaufman JM, Audran M, Bianchi G, et al. Strontium is similar to calcium. Robinson, R. G., Spicer, J. 2008;23(3):433-438. View abstract. While it may seem intimidating at first, counting macros is a common Erythritol is now one of the most popular natural zero-calorie sweeteners available. strontium is unlikely to have a net beneficial effect in osteoporosis and its use is declining as a consequence. Previous research demonstrates that strontium ranelate can promote bone formation while decreasing vertebral and nonvertebral fracture risk in women with postmenopausal osteoporosis. 2010;21(4):667-677. View abstract. 1990;1(1):19-23. Lets take a look at the possible health benefits of strontium. View abstract. Strontium absorption also has effects on the absorption ofcalcium, magnesium and phosphate ions. Cochrane Musculoskeletal Group. Reichenbach, S., Blank, S., Rutjes, A. W., Shang, A., King, E. A., Dieppe, P. A., Juni, P., and Trelle, S. Hylan versus hyaluronic acid for osteoarthritis of the knee: a systematic review and meta-analysis. Biol.Trace Elem.Res. Roque, I. Figuls, Martinez-Zapata, M. J., Scott-Brown, M., and Alonso-Coello, P. Radioisotopes for metastatic bone pain. Erythritol: Is This Healthy Sweetener the Real Deal? Clinically meaningful effect of strontium ranelate on symptoms in knee osteoarthritis: a responder analysis.